Research Progress of Cyclophilin A in Pulmonary Infectious Diseases
Keywords:
Cyclophilin A, Chronic airway inflammation, Acute respiratory distress syndrome, Viral pneumoniaAbstract
Cyclophilin A (CyPA) is an immunophilin with peptidyl-prolyl cis-trans isomerase (PPIase) activity, widely expressed in various tissues and organs, including the lungs. Under inflammatory responses or external cytokine stimulation, CyPA is secreted extracellularly and binds to receptors such as CD147, activating signaling pathways like ERK/NF-κB. This promotes inflammatory cell chemotaxis and cytokine release, playing a role in the pathophysiological processes of various inflammatory diseases. The expression level of CyPA is positively correlated with the severity of inflammation in pulmonary diseases such as chronic airway inflammation, acute respiratory distress syndrome (ARDS), and COVID-19 pneumonia. Targeting CyPA has been shown to reduce inflammation and improve prognosis. This article reviews the research progress of CyPA in common pulmonary infectious diseases, providing insights into its mechanism of action in such conditions.
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