The Role of B Lymphocyte Stimulator/A Proliferation-Inducing Ligand in Neuroimmune Diseases
Keywords:
B-cell activating factor, A proliferation-inducing ligand, Neuroimmune diseases, PathogenesisAbstract
B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), both belonging to the tumor necrosis factor superfamily, exhibit significant homology. Functioning as lymphocyte co-stimulators, BLyS and APRIL regulate various biological processes, including cell differentiation, proliferation, survival, and importantly, immune functions of B and T cells. These molecules play a pivotal role in the pathogenesis and progression of neuroimmune diseases, such as neuromyelitis optica spectrum disorders, multiple sclerosis, and myasthenia gravis. This paper aims to enhance the understanding of BLyS/APRIL and their involvement in neuroimmune diseases.
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