Research Progress on Drug Therapy for Retinal Vein Occlusion Combined with Macular Edema

Authors

    Junhan Xu, Ning Zhang Beijing Luhe Hospital, Capital Medical University, Beijing 100069, China Beijing Luhe Hospital, Capital Medical University, Beijing 100069, China

DOI:

https://doi.org/10.18063/apm.v10i2.889

Keywords:

Retinal vein occlusion, Macular edema, Combined treatment, Drug therapy

Abstract

As a common cause of blindness in retinal vascular diseases, retinal vein occlusion (Retinal vein occlusion, RVO) often leads to macular edema (macular edema, ME), which is the core pathological link causing central vision loss in patients. In recent years, with the innovative application of anti-vascular endothelial growth factor (anti-vascular endothelial growth factor, VEGF) agents, breakthroughs in sustained-release glucocorticoid technology, and the promotion of multimodal combined therapy strategies, clinical management of RVO-associated ME has entered a new phase of precision treatment. This review is based on evidence from evidence-based medicine, systematically analyzing the latest advancements in the pharmacological treatment system for RVO-ME, and proposes new directions for exploration from a translational medicine perspective, addressing current research gaps.

References

Ciulla T, Pollack J, Williams D, 2021, Visual Acuity Outcomes and Anti-VEGF Therapy Intensity in Macular Oedema Due to Retinal Vein Occlusion: A Real-World Analysis of 15613 Patient Eyes. Br J Ophthalmol, 105(12): 1696–1704.

Zhu X, Yu Y, Zhuoga S, et al., 2022, Real-World Outcomes of Anti-Vascular Endothelial Growth Factor Therapy for Retinal Vascular Vein Occlusion in Tibet, China. Int J Ophthalmol, 15(11): 1814–1820.

Hirai H, Yamashita M, Matsumoto M, et al., 2022, Alteration of Plasma von Willebrand Factor in the Treatment of Retinal Vein Occlusion with Cystoid Macular Edema. PLoS One, 17(9): e0264809.

Avery R, Castellarin A, Steinle N, et al., 2017, Systemic Pharmacokinetics and Pharmacodynamics of Intravitreal Aflibercept, Bevacizumab, and Ranibizumab. Retina, 37(10): 1847–1858.

Qin H, Shi F, Zhang C, et al., 2022, Anti-VEGF Reduces Inflammatory Features in Macular Edema Secondary to Retinal Vein Occlusion. Int J Ophthalmol, 15(8): 1296–1304.

Hwang D, Chang Y, Lin T, et al., 2020, Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion. Biomolecules, 10(10): 1414.

Hattenbach L, Chronopoulos A, Feltgen N, 2022, Retinal Vein Occlusion: Intravitreal Pharmacotherapies and Treatment Strategies for the Management of Macular Edema. Ophthalmologie, 119(11): 1100–1110.

Narayanan R, Kelkar A, Abbas Z, et al., 2021, Sub-Optimal Gain in Vision in Retinal Vein Occlusion Due to Under-Treatment in the Real World: Results from an Open-Label Prospective Study of Intravitreal Ranibizumab. BMC Ophthalmol, 21(1): 33.

Zhou H, Sun Z, Zhao M, et al., 2022, Prognostic Factor Study of Macular Edema Recurrence in Retinal Vein Occlusion after Conbercept Treatment: A Post Hoc Analysis of the FALCON Study. Comput Math Methods Med, 2022: 3616044.

Carnevali A, Bacherini D, Metrangolo C, et al., 2024, Long Term Efficacy and Safety Profile of Dexamethasone Intravitreal Implant in Retinal Vein Occlusions: A Systematic Review. Front Med (Lausanne), 11: 1454591.

Giuffrè C, Cicinelli M, Marchese A, et al., 2020, Simultaneous Intravitreal Dexamethasone and Aflibercept for Refractory Macular Edema Secondary to Retinal Vein Occlusion. Graefes Arch Clin Exp Ophthalmol, 258(4): 787–793.

Weijie Z, Yuanyuan D, Xiaoyan J, et al., 2022, Comparison of the Efficiency of Anti-VEGF Drugs Intravitreal Injections Treatment with or without Retinal Laser Photocoagulation for Macular Edema Secondary to Retinal Vein Occlusion: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology, 13: 948852.

Li L, Qian R, Zhaohui S, et al., 2022, Clinical Efficacy of Conbercept Plus Micropulse Laser (577 nm) Treatment in Macular Edema Secondary to Non-Ischemic Central Retinal Vein Occlusion. Pakistan Journal of Medical Sciences, 38(5): 1366–1370.

Li X, Chen Z, Liu X, 2024, Comparison of the Efficacy of Kangbepic and Lezumab Combined with Laser Photocoagulation in Treating Retinal Vein Occlusion Combined with Macular Edema. Chinese Journal of Drug and Clinical Practice, 24(24): 1595–1600.

Wang N, 2022, Comparison of the Efficacy of Laser Coagulation Combined with Intravitreal Injection of Conbercept or Lezumab for Retinal Branch Vein Occlusion and Macular Edema. Practical Anti-Blindness Technology, 17(4): 141–144.

Chen X, 2022, Long-Term Efficacy Observation and Predictive Factor Analysis of Laser Photocoagulation Combined with Leucovirin for Ischemic Retinal Branch Vein Occlusion Complicated with Macular Edema, thesis, Tongfang Knowledge Network (Beijing) Technology Co., Ltd.

Wang Y, Du Z, Wang T, et al., 2022, Observation on Efficacy and Safety of Lezhu Monoclonal Antibody Combined with Laser Photocoagulation for Treatment of Macular Edema Secondary to Retinal Branch Vein Occlusion. Guizhou Medical, 46(6): 947–948.

Yang D, Li L, 2019, Observation on the Efficacy of Lezhu Monoclonal Antibody Combined with Laser Photocoagulation in Treating Retinal Branch Vein Occlusion (BRVO) Secondary Macular Edema. New Progress in Ophthalmology, 39(4): 369–372.

Jiao W, Ma N, Wang S, et al., 2018, Observation on the Efficacy of Lezhu Monoclonal Antibody Combined with Triamcinolone Acetonide Intravitreal Injection in Treating Retinal Branch Vein Occlusion with Macular Edema. Clinical Medical Literature Electronic Journal, 5(12): 34–35 + 37.

Cao Z, Yang Y, Liu Y, 2022, Clinical Efficacy of Intravitreal Injection of Bevacizumab Combined with Laser Photocoagulation for Ischemic Retinal Branch Vein Occlusion Macular Edema. Journal of Rational Clinical Drug Use, 15(15): 155–158.

Li S, Gao R, Chen H, 2016, Efficacy of Lezhu Monoclonal Antibody Combined with Argon Laser Retinal Photocoagulation in Treating Macular Edema Caused by Retinal Branch Vein Occlusion at Different Periods. New Progress in Ophthalmology, 36(12): 1161–1164.

Wang X, 2017, Observation on the Efficacy of Intravitreal Injection of Lezumab Combined with Triamcinolone or Laser Photocoagulation in Treating Macular Edema Secondary to Retinal Branch Vein Occlusion. Chinese Journal of Practical Medicine, 12(2): 110–112.

Shi H, Ma K, Zheng C, 2022, Efficacy of Lezhu Monoclonal Antibody Combined with Photocoagulation in Treating Macular Edema Secondary to Central Retinal Vein Occlusion. Journal of North Sichuan Medical College, 37(2): 252–255.

Lantu C, Xie L, Luo C, et al., 2024, Efficacy of Combretastine Combined with Laser Photocoagulation in Treating Retinal Branch Vein Occlusion with Macular Edema. Journal of Clinical Ultrasound in Medicine, 26(12): 1016–1020.

Liu J, Yue S, 2024, The Effect of Intravitreal Injection of Conbercept Combined with Laser Photocoagulation on the Treatment of Retinal Vein Occlusion Combined with Macular Edema. Medical Frontiers, 14(31): 47–49.

Xu F, 2020, Clinical Observation on the Efficacy of Combined Retinal Photocoagulation and Kangbepic for Retinal Vein Occlusion with Macular Edema, thesis, Tongfang Knowledge Network (Beijing) Technology Co., Ltd.

Zhao Q, 2021, The Efficacy of Kangbepic Combined with Retinal Laser Photocoagulation in the Treatment of Retinal Vein Occlusion with Macular Edema. Clinical Medicine, 41(10): 79–81.

Shi Y, Xu Y, Zhang H, et al., 2020, Efficacy and Safety of Intravitreal Injection of Conbercept Combined with Selective Photocoagulation for the Treatment of Central Retinal Vein Occlusion Complicated by Macular Edema. Journal of Guangxi Medical University, 37(12): 2241–2245.

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Published

2025-06-28