Mechanical Stress Research and Regenerative Rehabilitation after Mesenchymal Stem Cell Treatment in People with Knee Osteoarthritis
Keywords:
Knee osteoarthritis, Articular cartilage, Mesenchymal stem cell, Regenerative rehabilitation, ExerciseAbstract
Mesenchymal stem cells (MSCs) have emerged as a cell type with great potential for cell-based articular cartilage repair in patients with knee osteoarthritis (OA). However, a meta-analysis of clinical trials of the MSC treatment revealed that current evidence about articular cartilage regeneration and objectively measured functional improvement in people with knee OA was inconclusive. Research for regenerative rehabilitation, a recently emerged interdisciplinary field, could contribute to establishing effective cell-based therapy that maximizes cartilage regeneration and functional improvement in people with knee OA. We herein summarize our cross-disciplinary approaches toward establishing effective regenerative rehabilitation in MSC-based treatment for people with knee OA. This review would serve as the foundation for future studies investigating the effects of rehabilitative approaches in regenerative medicine that lead to the clinical success of cell-based treatment.
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