The supporting principle of microtubule cytoskeleton dynamic assembly for cell polarity establishment

Authors

    André F. Vieira Epithelial Interactions in Cancer (EPIC) group, i3S, Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal

Keywords:

Microtubule cytoskeleton, Dynamic assembly, Cell polarity

Abstract

This article aims to elaborate on the supporting principles of microtubule cytoskeleton dynamic assembly for the establishment of cell polarity. Cell polarity is a crucial concept in cell biology, referring to the spatial asymmetry of intracellular molecules and structures, which is essential for cell differentiation and functional implementation. As an important component of the cytoskeleton, microtubules undergo a dynamic assembly process that includes nucleation, polymerization, and stabilization phases, regulated by various factors and exhibiting significant dynamic instability. The microtubule cytoskeleton provides critical support for the establishment of cell polarity by influencing intracellular transport, organelle localization, and signal transduction, playing an indispensable role in cellular physiological activities and developmental processes.

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Published

2025-02-25