The maintenance mechanism of lysosomal membrane stability and its effect on the process of autophagy
Keywords:
Lysosome, Membrane stability, Autophagy, Maintenance mechanismAbstract
This article aims to delve into the maintenance mechanism of lysosomal membrane stability and its critical role in the process of autophagy. First, the basic structure and function of lysosomes are elaborated. Then, a detailed analysis of the mechanisms that maintain lysosomal membrane stability is provided, including the role of membrane proteins, the influence of lipid composition, and the regulation of intracellular environmental factors. Subsequently, the close connection between lysosomal membrane stability and the process of autophagy is explored, discussing aspects such as the fusion of autophagosomes with lysosomes, the release of lysosomal hydrolases, and activity regulation. Finally, future research directions for lysosomal membrane stability are prospected, aiming to provide a theoretical foundation and new ideas for research in related fields.
References
Zhang S, 2022, The "purification system" of cells - lysosomes. Biology Teaching, 47(11): 90-92.
Chen Y, Zhu S, Hu S, et al., Molecular mechanism of lysosomal membrane permeabilization induced by Newcastle disease virus and its regulation of apoptosis. China Animal Husbandry and Veterinary Medicine Animal Infectious Diseases Branch. Proceedings of the 19th National Academic Seminar of the Animal Infectious Diseases Branch of the China Animal Husbandry and Veterinary Medicine Association. Yangzhou University School of Veterinary Medicine, 2021: 1. https://doi.org/10.26914/c.cnkihy.2021.080823.
Wu C, Zhang Y, Li W, et al., 2021, Study on the anti-proliferative effect of extracts from Lingshuianluo, a traditional Chinese medicine, on renal cancer cells mediated by increased lysosomal membrane permeability. Shizhen Guoyi Guoyao, 32(02): 315-318.
Feng J, 2020, AXIN regulates mTORC1 through the lysosomal pathway. Xiamen University. https://doi.org/10.27424/d.cnki.gxmdu.2020.004317.
Song B, Liu X, Zhang Y, et al., Lysosomal lesions and amyotrophic lateral sclerosis. Journal of Brain and Nervous Diseases, 27(01): 58-62.
Wang Z, Cheng L, Cao Y, et al., 2013, Effects of ulinastatin on lysosomal membrane stability and coagulation function during perioperative double valve replacement. Journal of Cardiovascular Surgery (Electronic Edition), 2(03): 115-120.
Ni Y, 2018, Inhibition of RIP1 kinase enhances the stability of lysosomal membranes in ischemic astrocytes and its mechanism dependent on Hsp70.1B regulation. Soochow University.
Zhang J, Yu Q, Han L, et al., 2018, Study on the involvement of lysosomal cathepsin in AIF-mediated apoptosis in postmortem beef. Journal of Agricultural Machinery, 49(03): 354-360.
Zhu Y, Inhibition of autophagy enhances lysosomal membrane stability in ischemic astrocytes by up-regulating lysosomal membrane Hsp 70.1B. Soochow University.
Devrim B, Wang Y, 2016, Preparation, characterization, and colloidal stability evaluation of lipid-polymer hybrid nanoparticles loaded with lysosomes. Chinese Journal of Pharmaceutical Industry, 47(11): 1453.