A Review of Pharmaceutical and Clinical Studies of the Cholesterol-Lowering Drug PCSK9 Inhibitor Inclisiran
Keywords:
Inclisiran, Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors, siRNA therapy, Low-density lipoprotein cholesterolAbstract
Hypercholesterolemia can lead to atherosclerosis, which in turn can cause a range of cardiovascular and cerebrovascular diseases. As the first drug approved by the US Food and Drug Administration in 2021 to lower low-density lipoprotein cholesterol through siRNA therapy, inclisiran’s sustained potent lipid-lowering effect and safety profile make it a promising treatment option for dyslipidemia. This article reviews the latest research progress on the mechanism of action, pharmacokinetic properties, efficacy, and safety of inclisiran. It also briefly explains its unique clinical administration method, aiming to provide a reference for the clinical use of inclisiran.
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