Mechanism of TCM Intervention in Protease-Antiprotease Imbalance in Chronic Obstructive Pulmonary Disease: A Review

Authors

    Mengjiao Xu, Haiqiang Wang, Wei Wang, Huimei Liu, Li Li, Jun Yan, Feng Gao Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China

Keywords:

Chronic obstructive pulmonary disease, Protease-antiprotease imbalance, Pathogenesis, Clinical trial, Basic experiment, TCM, Research progress

Abstract

The pathogenesis of chronic obstructive pulmonary disease (COPD) involves inflammation, oxidative stress, and protease-antiprotease imbalance. Among these, the protease-antiprotease imbalance is one of the main mechanisms of COPD. Increased protease can damage lung tissue by participating in inflammation, degrading the extracellular matrix, and remodeling the airways. In recent years, a large number of clinical trials and basic studies have been carried out with protease-antiprotease imbalance as a breakthrough point, accumulating fruitful results.

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Published

2024-06-26