Research Progress on Mechanism of Autophagy in Prevention and Treatment of Diabetic Peripheral Neuropathy by Traditional Chinese Medicine
Keywords:
Autophagy, Diabetic peripheral neuropathy, Schwann cell, Traditional Chinese medicine, Regulation and control mechanism, ReviewAbstract
Diabetic peripheral neuropathy (DPN) has a long course and poor prognosis, characterized by axonal degeneration and necrosis, segmental demyelination of nerve fibers, apoptosis of Schwann cells, and other neuronal cell injuries. Autophagy, the cleaning mechanism of nerve cells, eliminates damage caused by cellular stressors by clearing excess metabolites, thereby maintaining intracellular homeostasis. The sustained high glucose environment alters the level of autophagy in the body. Inhibition or excessive activation of autophagy can cause irreversible damage to nerve cells, accelerating the progression of DPN. Restoring autophagy balance is crucial for reducing nerve damage and treating DPN. Currently, there is no satisfactory treatment for DPN. Traditional Chinese medicine, with its unique advantages of multiple targets, multiple effects, and multiple components, has achieved good clinical effects in the prevention and treatment of DPN. Numerous animal and clinical studies on the treatment of DPN by traditional Chinese medicine have shown that autophagy is an important target for the treatment of DPN. Restoring autophagy balance can reduce nerve injury, delay the process of nerve cell death, and play a role in the prevention and treatment of DPN. However, its specific mechanism remains unknown. This paper focuses on the regulation of autophagy and its mechanism of action in the pathogenesis of DPN, as well as the intervention effect of single traditional Chinese medicine or compound effective ingredients on autophagy. It further explores the pathogenesis of DPN and potential therapeutic targets of traditional Chinese medicine intervention in autophagy, providing a reference for further improving the efficacy of traditional Chinese medicine in treating DPN.References
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