Exploring the Main Patterns of Evidence and Medication Patterns and Target Prediction of Yang Xiaocui’s Treatment of CKD Stage 3-4 Based on Data Mining
Keywords:
CKD, Data mining, Chinese medicine heritage computing platform, Network pharmacology, Medication patterns, Target predictionAbstract
Taking the Chinese medicine prescriptions of famous Chinese medicine practitioner Yang Xiaocui of Zunyi Hospital of Traditional Chinese Medicine for treating CKD stage 3–4 in the past 1 year as the source of data, the Chinese medicine prescriptions were analyzed for evidence type, frequency, association rules, and clustering by using Chinese medicine inheritance computation platform to obtain the main evidence type and core prescriptions, and on this basis, the research method of network pharmacology was used to screen the core targets and analyze them by KEGG pathway and GO function enrichment. The potential targets of HF drugs and diseases were studied to elucidate their mechanisms of action. A total of 158 outpatient medical records were collected, in which 153 Chinese herbal medicines were involved, including Huangqi, Shengdihuang, Chuanxiong, etc., which were mainly used to tonify deficiency, clear away heat and pacify the liver to calm the wind, and were mainly cold and sweet, and were mainly used in the liver meridian, spleen meridian and lung meridian, etc. Further, the frequency statistics and correlation analyzes were performed to obtain 10 high-frequency and 10 core drugs. By applying the research method of network pharmacology, the study explored the mechanism of action of the core group of Huangqi-Chuanxiong-Shengdihuang-Liuyuexue-Heichou (Qianniuzi), and found that its main active ingredients, such as quercetin, isorhamnetin and kaempferol, acted on the key targets of CA2, MAPT, ESR1, CYP19A1 and ESR2, and might be related to P53 signaling, insulin resistance, α-linolenic acid metabolism, inflammatory mediator regulation of TRP channels, longevity regulation pathway, and signaling pathway regulating stem cell pluripotency. Chinese herbal tonics are often used to treat CKD stage 3–4 by treating both the symptoms and the root cause, benefiting the kidney and draining the turbidity, with considerable clinical efficacy, and the HF drugs may play a therapeutic role through multiple signaling pathways, such as P53 signaling pathway, insulin resistance, and so on.
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